Phage DNA packaging occurs by DNA translocation into a prohead. Terminases are enzymes which initiate DNA packaging by cutting the DNA concatemer, and they are closely fitted structurally to the portal vertex of the prohead to form a ‘packasome’. Analysis among a number of phages supports an active role of the terminases in coupling ATP hydrolysis to DNA translocation through the portal. In phage T4 the small terminase subunit promotes a sequence‐specific terminase gene amplification within the chromosome. This link between (...) recombination and packaging suggests a DNA synapsis mechanism by the terminase to control packaging initiation, formally homologous to eukaryotic chromosome segregation. (shrink)

The AMA Council on Ethical and Judicial Affairs (CEJA) has written a position paper on how social medical use challenges medical professionalism. The report offers persuasive ethical and practical guidelines for nonclinical internet use, specifically for social networking.This commentary provides a framework from which to apply these guidelines, but adds that there may be important situations in which physicians are not able to act in accordance. The guidelines call for professional reporting of questionable online portrayals or behaviors, but this commentary (...) argues that this may be not only cumbersome to implement, but may violate aspects of constitutional rights. While online social networking may in many ways be a new application of old challenges, there may be other aspects that require novel approaches to medical professionalism. (shrink)

Caper in his section on the preposition ex cited Ennius, Ann. 309:nauibus explebant sese terrasque replebant,and declared that Virgil used the verb with this antique sense in Aen. 6, 545:discedam; explebo numerum reddarque tenebris,i.e. ‘minuam vestrum numerum.’This we are told in Servius' note, which begins: Ut diximus supra, explebo est minuam. Thilo gives no reference to any such previous words of Servius, and I have failed to find them. Can it be that Servius has carelessly transcribed a note of Donatus, (...) and that Donatus had discussed ex minuens at Geo. 2, 65, or 4, 145? Donatus' note on Terence, Hec. 755, is Explere exinanire Terentianum est; the passage of Terence is:eas ad mulieres huc intro atque istuc iusiurandum idempolliceare illis: exple animum îs teque hoc crimine expedi,i.e., relieve their mind of suspicion against Pamphilus and free yourself from this charge. The phrase recurs in the next Scene :illis modo explete animum.i atque exple animum îs, coge ut credant. (shrink)

Mrs. Dall, in her article A Seventh-Century English Edition of Virgil , shows that Virgil glosses taken from marginalia in the same MS. of the poems often preserve something of their original coherence in the two kindred glossaries, Affatim and the Second Amplonian, in spite of all the reshuffling of these two collections. Thus a small group of Virgil items appears in Affatim on p. 491 of Goetz's apograph : Carecta, Crateras, etc. The second last of this ‘Virgil cluster’ is (...) Cada: vasa vinaria. It appears also in Ampl. II. Ca[t]da: vas vinaria, and in Ampl. I. Cada: vasa vinaria, and is apparently taken , ultimately or immediately, from a marginal annotation on Aen. 1, 195 ‘uina bonus quae deinde cadis onerarat Acestes’ for in the Virgil Glossary printed by Goetz in C.G.L. IV. 427–470 we find Cadis: vasis vinariis. (shrink)

In the Glossary-codex, Vat. Lat. 1469, written in the year 908, fol. 83 has been assigned to ‘glossae collectae.’ They begin : In Passione Apostolorum. Iussit eum inaumachia cathomis consumi. Cathomis: uirgis nodosis. Hie naumachia forum signat Romanorum quod Prorostris dicitur eo quod rostra, etc.. In Sancto Sebastiano. Saturnus apocatasticus : id est dispositor et destructor fatorum. Annus tuus ex diametro susceptus est. Diametrum est, etc. ‘Glossae collectae’ from the Bible and from Jerome's prefaces come next.

We use the format of a hypothetical case study to review issues related to pharmaceutical product approval and physician prescribing practices. In this case, a new FDA-approved drug is recommended for a patient who subsequently experiences an adverse event that may or may not be related to the prescription. This case raises a number of ethical and legal considerations physicians routinely face when deciding whether to recommend such drugs for their patients. Despite the need for ongoing observation by the regulatory (...) apparatus, physicians should be cognizant of the limitations of the drug approval system and the post-approval prescription drug surveillance system. We discuss physicians’ ethical obligations when faced with a newly approved drug, including seeking out independent sources of learning, reporting adverse effects, and notifying patients about limitations in available knowledge about therapeutic recommendations. (shrink)

The line is preserved in a passage of Consentius ‘De Barbarismis et Metaplasmis’ : sicut Lucilius ‘ore corupto’; dempsit enim unam litteram per metaplasmum, r; et Ennius ‘huic statuam,’ etc.

Everyone interested in Latin Etymology knows the last word on mehercle, that the old vocative of meus is prefixed to the old Second Declension form Herclus, Voc. -lě. Without discussing whether this explanation is wholly true or partly wrong, I wish here to disqualify two pieces of evidence. Both originate from a marginal annotation on Rufinus' translation of Eusebius' Church History in, I think, a seventh-century English MS. These marginalia were used for the Leyden Glossary and for the common source (...) of the E E and Corpus Glossaries. The compiler of Leid. transferred them unaltered to his pages; and in the section devoted to Rufinus glosses we find Mehercule: mi fortis. The other compiler often recasts them for dictionary purposes. He gave this item the form Herculus: fortis . But of course the original annotation mi fortis was a mere lucky guess, and the substitution of ‘Herculus’ for Hercules was sheer ignorance. (shrink)

That Isidore′s etymological encyclopaedia should still remain to be edited seems strange at first sight; a book which makes a bridge between ancient and modern learning, and gives us a picture of the arts and sciences in Spain in the seventh century. Arevalo′s edition has a fair text, but practically no apparatus criticus; Otto′s offers the variants of a few worthless MSS. to support a very poor text. Since Otto′s, published some eighty years ago, there have been promises of editions, (...) but no actual edition. (shrink)

Charisivs, in his chapter on Adverbs, cites for Hispane a line of Ennius' Annals : Hispane, non Romane memoretis loqui me. Professor Norden , the apostle of Combinations-forschung, combines this fact with another fact mentioned by Livy , the celebre per Hispaniam responsum of a Spanish town to a Roman embassy. But why does he ignore a third fact which must be brought into any combination that can be convincing—the quotation of this line of Ennius by Festus in a paragraph (...) which apparently deals with Graeco-Roman affinities ? (shrink)

It has been pointed out above that Festus in his quotations cares more for the completion of the line than of the sense. His normal form is one complete line. So the probability is that Liu. Andr. com. is an Iambic Senarius, with a dactyl in the first foot and hiatus at the pause in the sense.

The narrow limits of the apparatus criticus in the new Clarendon Press edition have excluded these suggestions, which may find a place here:I xxix, 4 Quaedam etiam facta sunt ex nominum deriuatione, ut a prudentia ‘prudens ’; quaedam etiam ex uocibus, ut a garrulitate ‘garrulus.’ Although garrulus is the traditional reading, the derivation elsewhere of garrulus from graculus, ‘a jackdaw,’ suggests that we may read here ut a garrulitate ‘graulus.’ For the jackdaw's name in Late Latin developed from gragulus to (...) graulus. (shrink)

Professor Postgate speaks of ‘the regrettable silence of the principal editors of Plautus upon the subject.’ As a minor editor, I beg to defend my colleagues by pointing out that the scansions dĭŭtíus and dyūtius are subject of a note in Dziatzko's and Hauler's editions of the Phormio of Terence and in the Plautus Report in Bursian of 1879 . Also that a reference to the index of my larger edition of the Captiui will show that the word is discussed (...) in my section on Prosody : ‘The same doubt exists regarding the scansion of diutius , the by-form of the fuller form dĭūtĭŭs .’. (shrink)

Since Teuffel's Römische Literatur mentions s.v. Varius the famous entry in the Monte Cassino MS. incipit thvestes varii, but ignores its occurrence in a Benevento MS. , it may be well to give some account of the latter codex. For I read with amusement a recent article in this journal in which the writer severely censured Mr. Garrod's ignorance of the entry in Paris 7530, but revealed his own ignorance by assuming that it was the scribe of the Paris MS. (...) who had the lost tragedy of Varius before him. (shrink)

Gellia, of noble lineage, swore she would marry no one lower than a peer, but ultimately flung herself away on—whom? Nupsisti, Gellia, cistifero, say the two best families of MSS.; nupsisti, Gellia, cistibero says the third.